Nuclear Lamins And Laminopathies. Request PDF Nuclear lamins and laminopathies Nuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina on the inner aspect of the inner nuclear membrane. Lamin proteins are involved in the disassembling and reforming of the nuclear envelope during mitosis the positioning of nuclear pores and programmed cell death.
An emerging role in gene regulation and pathogenesis of laminopathies. Laminopathies and their role in premature ageing. 1Departments of Medicine and of Pathology and Cell Biology College of Physicians and Surgeons Columbia University New York USA.
Translocation of active genes into the close proximity of nuclear lamina is thought to result in their transcriptional silencing.
The family of laminopathies is a fast-growing group of diseases caused by abnormalities in the structure or processing. Decades of studies have established that nuclear lamin polymers form the nuclear lamina a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery. Lamin proteins are involved in the disassembling and reforming of the nuclear envelope during mitosis the positioning of nuclear pores and programmed cell death. Lamins are expressed in all mammalian somatic cells.